N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine

N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine - Names and Identifiers

Name	4-Methyl-3-[4-(3-pyridyl)pyrimidin-2-ylamino]aniline
Synonyms	Imatinib Imp.C IMatinib IMpurity C Imatinib Impurity 20 Imatinib EP Impurity F 4-Methyl-3-[4-(3-pyridyl)pyrimidin-2-ylamino]aniline N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine (5,AMINO 2-MethylPHENYL) 4,(3,PYRIDYL) 2,PYRIMIDINEAMINE N-(5-amino-2-methylphenyl)-4-(3-pyrdyl)-2-pydimidineamine N-(5-amino-2-methylphenl)-4-(3-pyridyl)-2-pyrimidine-amine N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine N-(2-methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidine amine N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-Benzenediamine 4-methyl-N~3~-(4-pyridin-3-ylpyrimidin-2-yl)benzene-1,3-diamine 4-Methyl-N'-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine 6-methyl-N'-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine N-(5-Amino-o-tolyl)-4-(3-pyridyl)-2-pyrimidinamine 4-Methyl-N3-[4-(3-pyridyl)-2-pyrimidinyl]-1,3-phenylenediamine N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine 4-Methyl-3-[4-(3-pyridyl)pyrimidin-2-ylamino]aniline
CAS	152460-10-1
EINECS	1806241-263-5
InChI	InChI=1/C16H15N5/c1-11-4-5-13(17)9-15(11)21-16-19-8-6-14(20-16)12-3-2-7-18-10-12/h2-10H,17H2,1H3,(H,19,20,21)
InChIKey	QGAIPGVQJVGBIA-UHFFFAOYSA-N

N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine - Physico-chemical Properties

Molecular Formula	C16H15N5
Molar Mass	277.32
Density	1.266±0.06 g/cm3(Predicted)
Melting Point	133-1350C
Boling Point	537.3±60.0 °C(Predicted)
Flash Point	278.765°C
Solubility	Soluble in DMSO and Methanol.
Vapor Presure	0mmHg at 25°C
Appearance	Bright yellow powder
Color	Yellow to Dark Yellow
pKa	4.77±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,2-8°C
Refractive Index	1.688
MDL	MFCD09028125
Use	Imatinib Intermediate

N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine - Risk and Safety

HS Code

29335990

N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine - Reference Information

imatinib

imatinib is the first generation tyrosine kinase inhibitor, a milestone drug in the history of treating chronic myeloid leukemia (CML), launched by Novartis in 2001, and is a successful model of targeted therapy. Only kill the BCR-ABL contained in myeloid cells, prevent cell proliferation and tumor formation, and have no effect on normal cells. It can also inhibit PDGF-mediated tumors, including glioma and prostate cancer. In the 1980s, scientific research showed that the granulocytes of most patients with chronic myeloid leukemia have two chromosomes transposed, resulting in a fusion kinase BCR-ABL, which led to the continuous activation of the kinase activity, resulting in uncontrolled cell proliferation-Blood cancer. On this basis, Dr. Druker, a biologist at Oregon University of Health Sciences in the United States, proposed the hypothesis of using BCR-ABL as a drug target and proposed the development of kinase inhibitors at this target to treat chronic myeloid leukemia. The second is the screening and optimization of the lead substance: then, Druker cooperated with Novartis chemist Nick Lydon to screen out small molecule inhibitors that inhibit BCR-ABL kinase from the compound library and optimized them to develop imatinib. Third, the results of preclinical studies and clinical trials show that imatinib is safe and effective. The vast majority of CML patients have achieved complete hematological remission, and the side effects are much less than cytotoxic anti-tumor drugs.

Use

Imatinib intermediate

Last Update：2024-04-09 20:49:11

N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine

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Wuhan Boye Science And Technology Development Co., Ltd.

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Shanghai Worldyang Chemical Co.,Ltd.

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Hangzhou FST pharmaceutical Co., Ltd

N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine

4-Methyl-3-[4-(3-pyridyl)pyrimidin-2-ylamino]aniline

CAS: 152460-10-1

Molecular Formula: C16H15N5

N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine - Names and Identifiers

N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine - Physico-chemical Properties

N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine - Risk and Safety

N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine - Reference Information

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N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine Request for Quotation

4-Methyl-3-[4-(3-pyridyl)pyrimidin-2-ylamino]aniline

CAS: 152460-10-1

Molecular Formula: C16H15N5

N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine - Names and Identifiers

N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine - Physico-chemical Properties

N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine - Risk and Safety

N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine - Reference Information

Supplier List

N-(2-Methyl-5-Amino Phenyl)-4-(3-Pyridyl)-2-Pyrimidine